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ICAM3 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P32942 |
|---|---|
| Clone Names | 100427070 |
| Gene ID | 3385 |
|---|---|
| Other Names | Intercellular adhesion molecule 3, ICAM-3, CDw50, ICAM-R, CD50, ICAM3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13708c was selected from the Center region of ICAM3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ICAM3 |
|---|---|
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha- L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of theintercellular adhesion molecule (ICAM) family. All ICAM proteinsare type I transmembrane glycoproteins, contain 2-9immunoglobulin-like C2-type domains, and bind to the leukocyteadhesion LFA-1 protein. This protein is constitutively andabundantly expressed by all leucocytes and may be the mostimportant ligand for LFA-1 in the initiation of the immuneresponse. It functions not only as an adhesion molecule, but alsoas a potent signalling molecule.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Reuss, R., et al. Mult. Scler. 16(3):366-369(2010)
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