|Other Names||Intercellular adhesion molecule 3, ICAM-3, CDw50, ICAM-R, CD50, ICAM3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13708c was selected from the Center region of ICAM3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theintercellular adhesion molecule (ICAM) family. All ICAM proteinsare type I transmembrane glycoproteins, contain 2-9immunoglobulin-like C2-type domains, and bind to the leukocyteadhesion LFA-1 protein. This protein is constitutively andabundantly expressed by all leucocytes and may be the mostimportant ligand for LFA-1 in the initiation of the immuneresponse. It functions not only as an adhesion molecule, but alsoas a potent signalling molecule.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Reuss, R., et al. Mult. Scler. 16(3):366-369(2010)
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