|Other Names||Small ubiquitin-related modifier 1, SUMO-1, GAP-modifying protein 1, GMP1, SMT3 homolog 3, Sentrin, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Smt3C, Ubiquitin-like protein UBL1, SUMO1, SMT3C, SMT3H3, UBL1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13711a was selected from the N-term region of SUMO1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||SMT3C, SMT3H3, UBL1|
|Function||Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.|
|Cellular Location||Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Note=Recruited by BCL11A into the nuclear body.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is a member of the SUMO(small ubiquitin-like modifier) protein family. It functions in amanner similar to ubiquitin in that it is bound to target proteinsas part of a post-translational modification system. However,unlike ubiquitin which targets proteins for degradation, thisprotein is involved in a variety of cellular processes, such asnuclear transport, transcriptional regulation, apoptosis, andprotein stability. It is not active until the last four amino acidsof the carboxy-terminus have been cleaved off. Several pseudogeneshave been reported for this gene. Alternate transcriptional splicevariants encoding different isoforms have been characterized.
Jia, Z.L., et al. DNA Cell Biol. 29(11):675-680(2010)Kang, X., et al. Oncogene 29(41):5568-5578(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Cox, B., et al. PLoS ONE 5 (8), E11996 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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