|Other Names||Signal transducer and activator of transcription 4, STAT4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13722b was selected from the C-term region of STAT4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the STATfamily of transcription factors. In response to cytokines andgrowth factors, STAT family members are phosphorylated by thereceptor associated kinases, and then form homo- or heterodimersthat translocate to the cell nucleus where they act astranscription activators. This protein is essential for mediatingresponses to IL12 in lymphocytes, and regulating thedifferentiation of T helper cells.
Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)Gestermann, N., et al. Genes Immun. 11(5):432-438(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Vuong, M.T., et al. PLoS ONE 5 (5), E10559 (2010) :Glas, J., et al. PLoS ONE 5 (4), E10373 (2010) :
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