|Other Names||Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, CD32, FCG2, FCGR2A1, IGFR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13724b was selected from the C-term region of FCGR2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD32, FCG2, FCGR2A1, IGFR2|
|Function||Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Found on monocytes, neutrophils and eosinophil platelets|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one member of a family of immunoglobulinFc receptor genes found on the surface of many immune responsecells. The protein encoded by this gene is a cell surface receptorfound on phagocytic cells such as macrophages and neutrophils, andis involved in the process of phagocytosis and clearing of immunecomplexes. Alternative splicing results in multiple transcriptvariants.
Dornan, D., et al. Blood 116(20):4212-4222(2010)Zhang, C.Y., et al. J. Biol. Chem. 285(44):34250-34258(2010)Iwasaki, M., et al. Breast Cancer Res. Treat. (2010) In press :Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :Sfar, I., et al. Arch Inst Pasteur Tunis 86 (1-4), 51-62 (2009) :
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