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FCGR2A Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P12318
Clone Names 100427124
Additional Information
Gene ID 2212
Other Names Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, CD32, FCG2, FCGR2A1, IGFR2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13724b was selected from the C-term region of FCGR2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FCGR2A
Synonyms CD32, FCG2, FCGR2A1, IGFR2
Function Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Found on monocytes, neutrophils and eosinophil platelets
Research Areas
Citations (0)
citation

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Background

This gene encodes one member of a family of immunoglobulinFc receptor genes found on the surface of many immune responsecells. The protein encoded by this gene is a cell surface receptorfound on phagocytic cells such as macrophages and neutrophils, andis involved in the process of phagocytosis and clearing of immunecomplexes. Alternative splicing results in multiple transcriptvariants.

References

Dornan, D., et al. Blood 116(20):4212-4222(2010)Zhang, C.Y., et al. J. Biol. Chem. 285(44):34250-34258(2010)Iwasaki, M., et al. Breast Cancer Res. Treat. (2010) In press :Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :Sfar, I., et al. Arch Inst Pasteur Tunis 86 (1-4), 51-62 (2009) :

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$ 277.78
Cat# BP13724b
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Availability: 2 weeks
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