|Other Names||Stromelysin-3, SL-3, ST3, 3424-, Matrix metalloproteinase-11, MMP-11, MMP11, STMY3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13729b was selected from the C-term region of MMP11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play an important role in the progression of epithelial malignancies.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Specifically expressed in stromal cells of breast carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. However, the enzyme encoded by thisgene is activated intracellularly by furin within the constitutivesecretory pathway. Also in contrast to other MMP's, this enzymecleaves alpha 1-proteinase inhibitor but weakly degrades structuralproteins of the extracellular matrix.
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Nalpas, B., et al. Gut 59(8):1120-1126(2010)Ban, J.Y., et al. Life Sci. 86 (19-20), 756-759 (2010) :Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
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