|Other Names||Matrix metalloproteinase-28, MMP-28, 3424-, Epilysin, MMP28, MMP25|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13734c was selected from the Center region of MMP28. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Can degrade casein. Could play a role in tissues homeostasis and repair.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix for both normalphysiological processes, such as embryonic development,reproduction and tissue remodeling, and disease processes, such asasthma and metastasis. This gene encodes a secreted enzyme thatdegrades casein. Its expression pattern suggests that it plays arole in tissue homeostasis and in wound repair. Transcript variantsencoding different isoforms have been described. [provided byRefSeq].
Swingler, T.E., et al. Biochem. J. 427(3):391-400(2010)Suomela, S., et al. Virchows Arch. 455(6):495-503(2009)Rodgers, U.R., et al. Matrix Biol. 28(5):263-272(2009)Heiskanen, T.J., et al. Matrix Biol. 28(2):74-83(2009)Gruber, H.E., et al. Arthritis Res. Ther. 11 (6), R184 (2009) :
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