|Other Names||Interleukin-13, IL-13, IL13, NC30|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13737b was selected from the C-term region of IL13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an immunoregulatory cytokine producedprimarily by activated Th2 cells. This cytokine is involved inseveral stages of B-cell maturation and differentiation. Itup-regulates CD23 and MHC class II expression, and promotes IgEisotype switching of B cells. This cytokine down-regulatesmacrophage activity, thereby inhibits the production ofpro-inflammatory cytokines and chemokines. This cytokine is foundto be critical to the pathogenesis of allergen-induced asthma butoperates through mechanisms independent of IgE and eosinophils.This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster onchromosome 5q, with this gene particularly close to IL4. [providedby RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Shi, X., et al. Anat Rec (Hoboken) 293(9):1470-1476(2010)Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :Zhao, M., et al. J. Biomed. Biotechnol. 2010, 931018 (2010) :
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