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CD27 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P26842 |
|---|---|
| Clone Names | 100427165 |
| Gene ID | 939 |
|---|---|
| Other Names | CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, CD27, TNFRSF7 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13740b was selected from the C-term region of CD27. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CD27 |
|---|---|
| Synonyms | TNFRSF7 |
| Function | Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Found in most T-lymphocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor is required for generationand long-term maintenance of T cell immunity. It binds to ligandCD70, and plays a key role in regulating B-cell activation andimmunoglobulin synthesis. This receptor transduces signals thatlead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteinsTRAF2 and TRAF5 have been shown to mediate the signaling process ofthis receptor. CD27-binding protein (SIVA), a proapoptotic protein,can bind to this receptor and is thought to play an important rolein the apoptosis induced by this receptor.
References
Jiang, J., et al. J. Clin. Immunol. 30(4):566-573(2010)Arimoto-Miyamoto, K., et al. Immunology 130(1):137-149(2010)Mizuochi, T., et al. J. Interferon Cytokine Res. 30(4):243-252(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Neron, S., et al. Arch. Immunol. Ther. Exp. (Warsz.) 57(6):447-458(2009)
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