|Other Names||CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, CD27, TNFRSF7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13740b was selected from the C-term region of CD27. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Found in most T-lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor is required for generationand long-term maintenance of T cell immunity. It binds to ligandCD70, and plays a key role in regulating B-cell activation andimmunoglobulin synthesis. This receptor transduces signals thatlead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteinsTRAF2 and TRAF5 have been shown to mediate the signaling process ofthis receptor. CD27-binding protein (SIVA), a proapoptotic protein,can bind to this receptor and is thought to play an important rolein the apoptosis induced by this receptor.
Jiang, J., et al. J. Clin. Immunol. 30(4):566-573(2010)Arimoto-Miyamoto, K., et al. Immunology 130(1):137-149(2010)Mizuochi, T., et al. J. Interferon Cytokine Res. 30(4):243-252(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Neron, S., et al. Arch. Immunol. Ther. Exp. (Warsz.) 57(6):447-458(2009)
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