|Other Names||Cadherin-16, Kidney-specific cadherin, Ksp-cadherin, CDH16|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13746b was selected from the C-term region of CDH16. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Kidney specific.|
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This gene is a member of the cadherin superfamily, genesencoding calcium-dependent, membrane-associated glycoproteins.Mapped to a previously identified cluster of cadherin genes onchromosome 16q22.1, the gene localizes with superfamily membersCDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of anextracellular domain containing 6 cadherin domains, a transmembraneregion and a truncated cytoplasmic domain but lacks the prosequenceand tripeptide HAV adhesion recognition sequence typical of mostclassical cadherins. Expression is exclusively in kidney, where theprotein functions as the principal mediator of homotypic cellularrecognition, playing a role in the morphogenic direction of tissuedevelopment.
Thedieck, C., et al. J. Mol. Biol. 378(1):145-153(2008)Kuehn, A., et al. Am. J. Surg. Pathol. 31(10):1528-1533(2007)Thedieck, C., et al. Br. J. Cancer 92(11):2010-2017(2005)Hishikawa, K., et al. Biochem. Biophys. Res. Commun. 328(1):288-291(2005)Wendeler, M.W., et al. Exp. Cell Res. 294(2):345-355(2004)
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