|Other Names||Signal transducer and activator of transcription 2, p113, STAT2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13749a was selected from the N-term region of STAT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the STATprotein family. In response to cytokines and growth factors, STATfamily members are phosphorylated by the receptor associatedkinases, and then form homo- or heterodimers that translocate tothe cell nucleus where they act as transcription activators. Inresponse to interferon (IFN), this protein forms a complex withSTAT1 and IFN regulatory factor family protein p48 (ISGF3G), inwhich this protein acts as a transactivator, but lacks the abilityto bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP)has been shown to interact specifically with this protein, which isthought to be involved in the process of blocking IFN-alpharesponse by adenovirus. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Lou, Y.J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(3):255-258(2010)Rosas-Murrieta, N.H., et al. Virol. J. 7, 263 (2010) :
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