|Other Names||Metabotropic glutamate receptor 4, mGluR4, GRM4, GPRC1D, MGLUR4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13750a was selected from the N-term region of GRM4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus No expression detected in liver.|
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Provided below are standard protocols that you may find useful for product applications.
L-glutamate is the major excitatory neurotransmitter inthe central nervous system and activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmissionis involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropicglutamate receptors are a family of G protein-coupled receptors,that have been divided into 3 groups on the basis of sequencehomology, putative signal transduction mechanisms, andpharmacologic properties. Group I includes GRM1 and GRM5 and thesereceptors have been shown to activate phospholipase C. Group IIincludes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibitionof the cyclic AMP cascade but differ in their agonistselectivities.
Muhle, H., et al. Epilepsy Res. 89 (2-3), 319-326 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009) :Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)Shibata, H., et al. Psychiatry Res 167 (1-2), 88-96 (2009) :
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