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MBD3 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O95983
Clone Names 100427244
Peptide ID 100427244
Additional Information
Gene ID 53615
Other Names Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3, MBD3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13755a was selected from the N-term region of MBD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBD3
Function Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases.
Cellular Location Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes
Research Areas
Citations (0)

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DNA methylation is the major modification of eukaryoticgenomes and plays an essential role in mammalian development. Humanproteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family ofnuclear proteins related by the presence in each of a methyl-CpGbinding domain (MBD). However, unlike the other family members,MBD3 is not capable of binding to methylated DNA. The predictedMBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) andmouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complexcontaining nucleosome remodeling and histone deacetylaseactivities. MBD3 mediates the association of metastasis-associatedprotein 2 (MTA2) with the core histone deacetylase complex.


Bachmann, N., et al. Eur J Med Genet 53(1):23-24(2010)Noh, E.J., et al. Biochem. Biophys. Res. Commun. 378(3):332-337(2009)Morey, L., et al. Mol. Cell. Biol. 28(19):5912-5923(2008)Brown, S.E., et al. Gene 420(2):99-106(2008)Spensberger, D., et al. Biochemistry 47(24):6418-6426(2008)

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$ 80.00
Cat# BP13755a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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