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MMP19 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q99542
Clone Names 100427264
Additional Information
Gene ID 4327
Other Names Matrix metalloproteinase-19, MMP-19, 3424-, Matrix metalloproteinase RASI, Matrix metalloproteinase-18, MMP-18, MMP19, MMP18, RASI
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13759a was selected from the N-term region of MMP19. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP19
Synonyms MMP18, RASI
Function Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients (PubMed:8920941)
Research Areas
Citations (0)
citation

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Background

Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. This protein is expressed in humanepidermis and it has a role in cellular proliferation as well asmigration and adhesion to type I collagen. Multiple transcriptvariants encoding distict isoforms have been identified for thisgene.

References

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :Muller, M., et al. Mod. Pathol. 23(4):511-521(2010)Lettau, I., et al. J. Neuropathol. Exp. Neurol. 69(3):215-223(2010)

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$ 277.78
Cat# BP13759a
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