CRMP1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q14194 |
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Clone Names | 100427265 |
Gene ID | 1400 |
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Other Names | Dihydropyrimidinase-related protein 1, DRP-1, Collapsin response mediator protein 1, CRMP-1, Unc-33-like phosphoprotein 3, ULIP-3, CRMP1, DPYSL1, ULIP3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13760a was selected from the N-term region of CRMP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CRMP1 |
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Synonyms | DPYSL1, ULIP3 |
Function | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). |
Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cell projection, growth cone {ECO:0000250|UniProtKB:P97427}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P97427}. Perikaryon {ECO:0000250|UniProtKB:P97427}. Note=Associated with centrosomes and the mitotic spindle during metaphase (PubMed:11562390). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity) {ECO:0000250|UniProtKB:P97427, ECO:0000269|PubMed:11562390} |
Tissue Location | Brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of a family of cytosolicphosphoproteins expressed exclusively in the nervous system. Theencoded protein is thought to be a part of the semaphorin signaltransduction pathway implicated in semaphorin-induced growth conecollapse during neural development. Alternative splicing results inmultiple transcript variants.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ingersoll, R.G., et al. Eur. J. Hum. Genet. 18(6):726-732(2010)Mukherjee, J., et al. Cancer Res. 69(22):8545-8554(2009)Mopert, K., et al. Exp. Cell Res. 315(13):2165-2180(2009)Sandebring, A., et al. PLoS ONE 4 (5), E5701 (2009) :
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