|Other Names||Dihydropyrimidinase-related protein 1, DRP-1, Collapsin response mediator protein 1, CRMP-1, Unc-33-like phosphoprotein 3, ULIP-3, CRMP1, DPYSL1, ULIP3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13760a was selected from the N-term region of CRMP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes and the mitotic spindle during metaphase|
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This gene encodes a member of a family of cytosolicphosphoproteins expressed exclusively in the nervous system. Theencoded protein is thought to be a part of the semaphorin signaltransduction pathway implicated in semaphorin-induced growth conecollapse during neural development. Alternative splicing results inmultiple transcript variants.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ingersoll, R.G., et al. Eur. J. Hum. Genet. 18(6):726-732(2010)Mukherjee, J., et al. Cancer Res. 69(22):8545-8554(2009)Mopert, K., et al. Exp. Cell Res. 315(13):2165-2180(2009)Sandebring, A., et al. PLoS ONE 4 (5), E5701 (2009) :
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