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TARDBP Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q13148
Clone Names 100427274
Peptide ID 100427274
Additional Information
Gene ID 23435
Other Names TAR DNA-binding protein 43, TDP-43, TARDBP, TDP43
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13763a was selected from the N-term region of TARDBP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TDP43
Function DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
Cellular Location Nucleus. Note=In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies
Tissue Location Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen
Research Areas
Citations (0)

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HIV-1, the causative agent of acquired immunodeficiencysyndrome (AIDS), contains an RNA genome that produces achromosomally integrated DNA during the replicative cycle.Activation of HIV-1 gene expression by the transactivator Tat isdependent on an RNA regulatory element (TAR) located downstream ofthe transcription initiation site. The protein encoded by this geneis a transcriptional repressor that binds to chromosomallyintegrated TAR DNA and represses HIV-1 transcription. In addition,this protein regulates alternate splicing of the CFTR gene. Asimilar pseudogene is present on chromosome 20. [provided byRefSeq].


Kim, S.H., et al. J. Biol. Chem. 285(44):34097-34105(2010)Geser, F., et al. Arch. Neurol. 67(10):1238-1250(2010)Mackenzie, I.R., et al. Lancet Neurol 9(10):995-1007(2010)Shan, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16325-16330(2010)McKee, A.C., et al. J. Neuropathol. Exp. Neurol. 69(9):918-929(2010)

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$ 80.00
Cat# BP13763a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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