|Other Names||CD97 antigen, Leukocyte antigen CD97, CD97, CD97 antigen subunit alpha, CD97 antigen subunit beta, CD97|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13768b was selected from the C-term region of CD97. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid|
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This gene is a member of the EGF-TM7 family of class IIseven-span transmembrane (7-TM) molecules, likely encoded by a genecluster on the short arm of chromosome 19. The encoded product is aglycoprotein that is present on the surface of most activatedleukocytes and spans the membrane seven times, which is a definingfeature of G protein-coupled receptors. The protein has an extendedextracellular region with several N-terminal epidermal growthfactor (EGF)-like domains, which mediate binding to its cellularligand, decay accelerating factor (DAF, CD55), a regulatory proteinof the complement cascade. The presence of structural featurescharacteristic of extracellular matrix proteins and transmembraneproteins suggests that this protein is a receptor involved in bothcell adhesion and signaling processes early after leukocyteactivation. Alternative splicing has been observed for this geneand three variants have been found.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Liu, D., et al. Int. J. Oncol. 36(6):1401-1408(2010)Han, S.L., et al. Int J Colorectal Dis 25(6):695-702(2010)van Eijk, M., et al. Immunol. Lett. 129(2):64-71(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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