|Other Names||Short transient receptor potential channel 5, TrpC5, Transient receptor protein 5, TRP-5, hTRP-5, hTRP5, TRPC5, TRP5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13769a was selected from the N-term region of TRPC5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the transient receptor family. Itencodes one of the seven mammalian TRPC (transient receptorpotential channel) proteins. The encoded protein is a multi-passmembrane protein and is thought to form a receptor-activatednon-selective calcium permeant cation channel. The protein isactive alone or as a heteromultimeric assembly with TRPC1, TRPC3,and TRPC4. It also interacts with multiple proteins includingcalmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor(NHERF ), interferon-induced GTP-binding protein (MX1), ring fingerprotein 24 (RNF24), and SEC14 domain and spectrin repeat-containingprotein 1 (SESTD1).
Al-Shawaf, E., et al. Arterioscler. Thromb. Vasc. Biol. 30(7):1453-1459(2010)Wong, C.O., et al. Pflugers Arch. 460(1):121-130(2010)Miehe, S., et al. J. Biol. Chem. 285(16):12426-12434(2010)Gross, S.A., et al. J. Biol. Chem. 284(49):34423-34432(2009)Everett, K.V., et al. Hum. Genet. (2009) In press :
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