|Other Names||Short transient receptor potential channel 5, TrpC5, Transient receptor protein 5, TRP-5, hTRP-5, hTRP5, TRPC5, TRP5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13769a was selected from the N-term region of TRPC5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole|
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This gene belongs to the transient receptor family. Itencodes one of the seven mammalian TRPC (transient receptorpotential channel) proteins. The encoded protein is a multi-passmembrane protein and is thought to form a receptor-activatednon-selective calcium permeant cation channel. The protein isactive alone or as a heteromultimeric assembly with TRPC1, TRPC3,and TRPC4. It also interacts with multiple proteins includingcalmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor(NHERF ), interferon-induced GTP-binding protein (MX1), ring fingerprotein 24 (RNF24), and SEC14 domain and spectrin repeat-containingprotein 1 (SESTD1).
Al-Shawaf, E., et al. Arterioscler. Thromb. Vasc. Biol. 30(7):1453-1459(2010)Wong, C.O., et al. Pflugers Arch. 460(1):121-130(2010)Miehe, S., et al. J. Biol. Chem. 285(16):12426-12434(2010)Gross, S.A., et al. J. Biol. Chem. 284(49):34423-34432(2009)Everett, K.V., et al. Hum. Genet. (2009) In press :
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