|Other Names||Synaptotagmin-2, Synaptotagmin II, SytII, SYT2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13771c was selected from the Center region of SYT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Note=Synaptic vesicles and chromaffin granules.|
|Tissue Location||Expressed in melanocytes (PubMed:23999003).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Synaptotagmins, like SYT2, are integral membrane proteinsof synaptic vesicles thought to serve as Ca(2+) sensors in theprocess of vesicular trafficking and exocytosis (Hilbush andMorgan, 1994 [PubMed 8058779]).
Young, S.M. Jr., et al. Neuron 63(4):482-496(2009)Han, C., et al. J. Immunol. 182(5):2986-2996(2009)Laohavisit, A., et al. Plant Cell 21(2):479-493(2009)Shi, J., et al. Biochem. Biophys. Res. Commun. 374(2):331-335(2008)Lee, B.H., et al. Mol. Cell 15(5):741-751(2004)
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