|Other Names||Synaptotagmin-2, Synaptotagmin II, SytII, SYT2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13771c was selected from the Center region of SYT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Note=Synaptic vesicles and chromaffin granules.|
|Tissue Location||Expressed in melanocytes (PubMed:23999003).|
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Provided below are standard protocols that you may find useful for product applications.
Synaptotagmins, like SYT2, are integral membrane proteinsof synaptic vesicles thought to serve as Ca(2+) sensors in theprocess of vesicular trafficking and exocytosis (Hilbush andMorgan, 1994 [PubMed 8058779]).
Young, S.M. Jr., et al. Neuron 63(4):482-496(2009)Han, C., et al. J. Immunol. 182(5):2986-2996(2009)Laohavisit, A., et al. Plant Cell 21(2):479-493(2009)Shi, J., et al. Biochem. Biophys. Res. Commun. 374(2):331-335(2008)Lee, B.H., et al. Mol. Cell 15(5):741-751(2004)
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