|Other Names||Nuclear receptor subfamily 0 group B member 1, DSS-AHC critical region on the X chromosome protein 1, Nuclear receptor DAX-1, NR0B1, AHC, DAX1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13774c was selected from the Center region of NR0B1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains a DNA-bindingdomain. The encoded protein acts as a dominant-negative regulatorof transcription which is mediated by the retinoic acid receptor.This protein also functions as an anti-testis gene by actingantagonistically to Sry. Mutations in this gene result in bothX-linked congenital adrenal hypoplasia and hypogonadotropichypogonadism.
Li, N., et al. J. Clin. Endocrinol. Metab. 95 (9), E104-E111 (2010) :Nedumaran, B., et al. J. Biol. Chem. 285(12):9221-9232(2010)Kinsey, M., et al. Cancer Res. 69(23):9047-9055(2009)Nagl, F., et al. Am. J. Physiol., Cell Physiol. 297 (5), C1146-C1156 (2009) :Skinningsrud, B., et al. J. Clin. Endocrinol. Metab. 94(10):4086-4093(2009)
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