|Other Names||Peroxisome proliferator-activated receptor delta, PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, PPARD, NR1C2, PPARB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13778b was selected from the C-term region of PPARD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.|
|Tissue Location||Ubiquitous with maximal levels in placenta and skeletal muscle|
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This gene encodes a member of the peroxisomeproliferator-activated receptor (PPAR) family. PPARs are nuclearhormone receptors that bind peroxisome proliferators and controlthe size and number of peroxisomes produced by cells. PPARs mediatea variety of biological processes, and may be involved in thedevelopment of several chronic diseases, including diabetes,obesity, atherosclerosis, and cancer. This protein is a potentinhibitor of ligand-induced transcription activity of PPAR alphaand PPAR gamma. It may function as an integrator of transcriptionrepression and nuclear receptor signaling. The expression of thisgene is found to be elevated in colorectal cancer cells. Theelevated expression can be repressed by adenomatosis polyposis coli(APC), a tumor suppressor protein related to APC/beta-cateninsignaling pathway. Knockout studies in mice suggested the role ofthis protein in myelination of the corpus callosum, lipidmetabolism, and epidermal cell proliferation. Alternate splicingresults in multiple transcript variants.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Christopoulos, P., et al. Ann. N. Y. Acad. Sci. 1205, 185-191 (2010) :Dunn, S.E., et al. J. Exp. Med. 207(8):1599-1608(2010)Eynon, N., et al. Mitochondrion (2010) In press :Jguirim-Souissi, I., et al. Genet. Mol. Res. 9(3):1326-1333(2010)
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