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DHRS7C Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | A6NNS2 |
|---|---|
| Clone Names | 100408110 |
| Gene ID | 201140 |
|---|---|
| Other Names | Dehydrogenase/reductase SDR family member 7C, 11--, DHRS7C |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13788c was selected from the Center region of DHRS7C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DHRS7C (HGNC:32423) |
|---|---|
| Function | NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal. Plays a role in the regulation of cardiac and skeletal muscle metabolic functions. Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal. Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes. Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid. |
| Cellular Location | Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CHS7}. Note=The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm In skeletal muscle, enriched in the longitudinal sarcoplasmic reticulum. {ECO:0000250|UniProtKB:Q8CHS7} |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
DHRS7C is a putative oxidoreductase (Potential).
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$ 277.78
Cat# BP13788c
Ordering Information
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