|Other Names||Phosphoinositide-3-kinase-interacting protein 1, Kringle domain-containing protein HGFL, PIK3IP1, HGFL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13792b was selected from the C-term region of PIK3IP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of hepatic phosphatidylinositol 3- kinase (PI3K) activity.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
PIK3IP1 is a novel protein that shares homology with the p85 subunit of phosphatidylinositol-3-Kinases (PI3Ks). The PI3K is essential for cell proliferation and Survival.The PIK3IP down regulates the activity of the PI3K and induces apoptosis by associating with p85 and p110 to form a complex, using the p85-like domain. However, there is no evidence to suggest that the PIK3IP1 prevents association of p85 and p110 as they associate with very high affinity.
Gao, P., et al. Beijing Da Xue Xue Bao 40(6):572-577(2008)He, X., et al. Cancer Res. 68(14):5591-5598(2008)Zhu, Z., et al. Biochem. Biophys. Res. Commun. 358(1):66-72(2007)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
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