|Other Names||Protein S100-A7, Psoriasin, S100 calcium-binding protein A7, S100A7, PSOR1, S100A7C|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13794a was selected from the N-term region of S100A7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm. Secreted. Note=Secreted by a non- classical secretory pathway|
|Tissue Location||Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the S100family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are localized in the cytoplasm and/or nucleus of awide range of cells, and involved in the regulation of a number ofcellular processes such as cell cycle progression anddifferentiation. S100 genes include at least 13 members which arelocated as a cluster on chromosome 1q21. This protein differs fromthe other S100 proteins of known structure in its lack of calciumbinding ability in one EF-hand at the N-terminus. This protein ismarkedly over-expressed in the skin lesions of psoriatic patients,but is excluded as a candidate gene for familial psoriasissusceptibility. The exact function of this protein is not known.
West, N.R., et al. Oncogene 29(14):2083-2092(2010)Tieu, D.D., et al. J. Allergy Clin. Immunol. 125(3):667-675(2010)Tripathi, S.C., et al. PLoS ONE 5 (8), E11939 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :West, N.R., et al. Protein Sci. 18(12):2615-2623(2009)
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