S100A7 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P31151 |
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Clone Names | 100430272 |
Gene ID | 6278 |
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Other Names | Protein S100-A7, Psoriasin, S100 calcium-binding protein A7, S100A7, PSOR1, S100A7C |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13794a was selected from the N-term region of S100A7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | S100A7 |
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Synonyms | PSOR1, S100A7C |
Cellular Location | Cytoplasm. Secreted. Note=Secreted by a non-classical secretory pathway |
Tissue Location | Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the S100family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are localized in the cytoplasm and/or nucleus of awide range of cells, and involved in the regulation of a number ofcellular processes such as cell cycle progression anddifferentiation. S100 genes include at least 13 members which arelocated as a cluster on chromosome 1q21. This protein differs fromthe other S100 proteins of known structure in its lack of calciumbinding ability in one EF-hand at the N-terminus. This protein ismarkedly over-expressed in the skin lesions of psoriatic patients,but is excluded as a candidate gene for familial psoriasissusceptibility. The exact function of this protein is not known.
References
West, N.R., et al. Oncogene 29(14):2083-2092(2010)Tieu, D.D., et al. J. Allergy Clin. Immunol. 125(3):667-675(2010)Tripathi, S.C., et al. PLoS ONE 5 (8), E11939 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :West, N.R., et al. Protein Sci. 18(12):2615-2623(2009)
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