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AP1G2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75843 |
|---|---|
| Clone Names | 100318131 |
| Gene ID | 8906 |
|---|---|
| Other Names | AP-1 complex subunit gamma-like 2, Gamma2-adaptin, G2ad, AP1G2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13809a was selected from the N-term region of AP1G2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AP1G2 |
|---|---|
| Function | May function in protein sorting in late endosomes or multivesucular bodies (MVBs). |
| Cellular Location | Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures (PubMed:9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed:16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed:11333915) |
| Tissue Location | Expressed in all but one (skeletal muscle) tissues examined |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Adaptins are important components of clathrin-coatedvesicles transporting ligand-receptor complexes from the plasmamembrane or from the trans-Golgi network to lysosomes. The adaptinfamily of proteins is compsed of four classes of molecules namedalpha, beta-, beta prime- and gamma- adaptins. Adaptins, togetherwith medium and small subunits, form a heterotetrameric complexcalled an adaptor, whose role is to promote the formation ofclathrin-coated pits and vesicles. The protein encoded by this geneis a gamma-adaptin protein and it belongs to the adaptor complexeslarge subunits family. This protein along with the complex isthought to function at some trafficking step in the complexpathways between the trans-Golgi network and the cell surface.There are two alternatively spliced transcript variants of thisgene encoding the same protein.
References
Doring, T., et al. Biochim. Biophys. Acta 1803(11):1252-1264(2010)Rost, M., et al. J. Biol. Chem. 283(46):32119-32130(2008)Lambert, C., et al. J. Virol. 81(17):9050-9060(2007)Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)Mattera, R., et al. J. Biol. Chem. 279(9):8018-8028(2004)
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