|Other Names||AP-1 complex subunit gamma-like 2, Gamma2-adaptin, G2ad, AP1G2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13809a was selected from the N-term region of AP1G2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).|
|Cellular Location||Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein Note=Mainly localized to perinuclear vesicular structures Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments. Colocalizes with HBV major surface antigen L to cis-Golgi-like structures|
|Tissue Location||Expressed in all but one (skeletal muscle) tissues examined|
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Provided below are standard protocols that you may find useful for product applications.
Adaptins are important components of clathrin-coatedvesicles transporting ligand-receptor complexes from the plasmamembrane or from the trans-Golgi network to lysosomes. The adaptinfamily of proteins is compsed of four classes of molecules namedalpha, beta-, beta prime- and gamma- adaptins. Adaptins, togetherwith medium and small subunits, form a heterotetrameric complexcalled an adaptor, whose role is to promote the formation ofclathrin-coated pits and vesicles. The protein encoded by this geneis a gamma-adaptin protein and it belongs to the adaptor complexeslarge subunits family. This protein along with the complex isthought to function at some trafficking step in the complexpathways between the trans-Golgi network and the cell surface.There are two alternatively spliced transcript variants of thisgene encoding the same protein.
Doring, T., et al. Biochim. Biophys. Acta 1803(11):1252-1264(2010)Rost, M., et al. J. Biol. Chem. 283(46):32119-32130(2008)Lambert, C., et al. J. Virol. 81(17):9050-9060(2007)Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)Mattera, R., et al. J. Biol. Chem. 279(9):8018-8028(2004)
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