|Other Names||EH domain-containing protein 1, PAST homolog 1, hPAST1, Testilin, EHD1, PAST, PAST1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13814b was selected from the C-term region of EHD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Plays a role in myoblast fusion. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth.|
|Cellular Location||Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Preferentially associates with tubular recycling endosomes. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes|
|Tissue Location||Highly expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to a highly conserved gene familyencoding EPS15 homology (EH) domain-containing proteins. Theprotein-binding EH domain was first noted in EPS15, a substrate forthe epidermal growth factor receptor. The EH domain has been shownto be an important motif in proteins involved in protein-proteininteractions and in intracellular sorting. The protein encoded bythis gene is thought to play a role in the endocytosis of IGF1receptors.
Gudmundsson, H., et al. Circ. Res. 107(1):84-95(2010)Sharma, M., et al. Mol. Biol. Cell 20(24):5181-5194(2009)Kieken, F., et al. Protein Sci. 18(12):2471-2479(2009)Jovic, M., et al. Mol. Biol. Cell 20(11):2731-2743(2009)Fichtman, B., et al. Cell. Mol. Biol. Lett. 13(4):632-648(2008)
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