|Other Names||Platelet receptor Gi24, Stress-induced secreted protein-1, Sisp-1, C10orf54, SISP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13817c was selected from the Center region of C10orf54. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
GI24 is a platelet receptor. It is a type I membrane protein and contains one immunoglobulin-like domain.
Sakr, M.A., et al. Cancer Sci. 101(11):2368-2374(2010)Lamesch, P., et al. Genomics 89(3):307-315(2007)Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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