SNX14 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y5W7 |
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Clone Names | 100406173 |
Gene ID | 57231 |
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Other Names | Sorting nexin-14, SNX14 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13820c was selected from the Center region of SNX14. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SNX14 |
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Function | Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25848753, PubMed:25148684). |
Cellular Location | Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHY8} |
Tissue Location | Widely expressed both in fetal and adult tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the sorting nexin family.Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellulartrafficking. The encoded protein also contains a regulator of Gprotein signaling (RGS) domain. Regulator of G protein signalingfamily members are regulatory molecules that act as GTPaseactivating proteins for G alpha subunits of heterotrimeric Gproteins. Two transcript variants encoding distinct isoforms havebeen identified for this gene.
References
Worby, C.A., et al. Nat. Rev. Mol. Cell Biol. 3(12):919-931(2002)Xu, Y., et al. Biochem. J. 360 (PT 3), 513-530 (2001) :Teasdale, R.D., et al. Biochem. J. 358 (PT 1), 7-16 (2001) :Carroll, P., et al. Dev. Dyn. 221(4):431-442(2001)
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