|Other Names||Discoidin, CUB and LCCL domain-containing protein 2, CUB, LCCL and coagulation factor V/VIII-homology domains protein 1, Endothelial and smooth muscle cell-derived neuropilin-like protein, DCBLD2, CLCP1, ESDN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13827b was selected from the C-term region of DCBLD2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells|
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DCBLD2, otherwise known as ESDN (endothelial and smooth muscle cell-derived neuropilin-like molecule) is a novel type-I transmembrane protein with the longest cleavable secretory signal sequence among eukaryotes. It is expressed in various tissues; particularly highly expressed in cultured vascular smooth muscle cells. DCBLD2 is considered to play a role in regulation of vascular cell growth and may have a wide variety of functions in other tissues including the nervous system, like neuropilins.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Guo, X., et al. J. Biol. Chem. 284(43):29376-29382(2009)Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)Kim, M., et al. Mol. Cancer Res. 6(2):222-230(2008)Sadeghi, M.M., et al. Am. J. Transplant. 7(9):2098-2105(2007)
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