|Other Names||Protein POF1B, Premature ovarian failure protein 1B, POF1B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13828c was selected from the Center region of POF1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development.|
|Cellular Location||Cell junction, tight junction|
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Premature ovarian failure (POF) is characterized byprimary or secondary amenorrhea in women less than 40 years old.Two POF susceptibility regions called 'POF1' and 'POF2' have beenidentified by breakpoint mapping of X-autosome translocations. POF1extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1.This gene, POF1B, resides in the POF2 region. This gene isexpressed at trace levels in mouse prenatal ovary and is barelydetectable or absent from adult ovary, in human and in the mouserespectively. This gene's expression is restricted to epitheliawith its highest expression in the epidermis, and oro-pharyngealand gastro-intestinal tracts. The protein encoded by this genebinds non-muscle actin filaments. The role this gene may play inthe etiology of premature ovarian failure remains to be determined.
Rizzolio, F., et al. Gene Expr. Patterns 7(4):529-534(2007)Lacombe, A., et al. Am. J. Hum. Genet. 79(1):113-119(2006)Bione, S., et al. Hum. Reprod. 19(12):2759-2766(2004)Bione, S., et al. Semin. Reprod. Med. 18(1):51-57(2000)Riva, P., et al. Clin. Genet. 50(4):267-269(1996)
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