POF1B Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8WVV4 |
---|---|
Clone Names | 100405161 |
Gene ID | 79983 |
---|---|
Other Names | Protein POF1B, Premature ovarian failure protein 1B, POF1B |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13828c was selected from the Center region of POF1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | POF1B |
---|---|
Function | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. |
Cellular Location | Cell junction, tight junction |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Premature ovarian failure (POF) is characterized byprimary or secondary amenorrhea in women less than 40 years old.Two POF susceptibility regions called 'POF1' and 'POF2' have beenidentified by breakpoint mapping of X-autosome translocations. POF1extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1.This gene, POF1B, resides in the POF2 region. This gene isexpressed at trace levels in mouse prenatal ovary and is barelydetectable or absent from adult ovary, in human and in the mouserespectively. This gene's expression is restricted to epitheliawith its highest expression in the epidermis, and oro-pharyngealand gastro-intestinal tracts. The protein encoded by this genebinds non-muscle actin filaments. The role this gene may play inthe etiology of premature ovarian failure remains to be determined.
References
Rizzolio, F., et al. Gene Expr. Patterns 7(4):529-534(2007)Lacombe, A., et al. Am. J. Hum. Genet. 79(1):113-119(2006)Bione, S., et al. Hum. Reprod. 19(12):2759-2766(2004)Bione, S., et al. Semin. Reprod. Med. 18(1):51-57(2000)Riva, P., et al. Clin. Genet. 50(4):267-269(1996)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.