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C1orf187 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NBI3 |
|---|---|
| Clone Names | 100406254 |
| Gene ID | 374946 |
|---|---|
| Other Names | Draxin {ECO:0000255|HAMAP-Rule:MF_03060}, Dorsal inhibitory axon guidance protein {ECO:0000255|HAMAP-Rule:MF_03060}, Dorsal repulsive axon guidance protein {ECO:0000255|HAMAP-Rule:MF_03060}, Neucrin, DRAXIN {ECO:0000255|HAMAP-Rule:MF_03060}, C1orf187 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13829b was selected from the C-term region of C1orf187. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DRAXIN {ECO:0000255|HAMAP-Rule:MF_03060} |
|---|---|
| Synonyms | C1orf187 |
| Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway (By similarity).
References
Miyake, A., et al. Biochem. Biophys. Res. Commun. 390(3):1051-1055(2009)Islam, S.M., et al. Science 323(5912):388-393(2009)Sullivan, P.F., et al. Mol. Psychiatry 13(6):570-584(2008)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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