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C1orf187 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NBI3
Clone Names 100406254
Peptide ID 100406254
Additional Information
Gene ID 374946
Other Names Draxin {ECO:0000255|HAMAP-Rule:MF_03060}, Dorsal inhibitory axon guidance protein {ECO:0000255|HAMAP-Rule:MF_03060}, Dorsal repulsive axon guidance protein {ECO:0000255|HAMAP-Rule:MF_03060}, Neucrin, DRAXIN {ECO:0000255|HAMAP-Rule:MF_03060}, C1orf187
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13829b was selected from the C-term region of C1orf187. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DRAXIN {ECO:0000255|HAMAP-Rule:MF_03060}
Synonyms C1orf187
Function Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway (By similarity).

References

Miyake, A., et al. Biochem. Biophys. Res. Commun. 390(3):1051-1055(2009)Islam, S.M., et al. Science 323(5912):388-393(2009)Sullivan, P.F., et al. Mol. Psychiatry 13(6):570-584(2008)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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$ 80.00
Cat# BP13829b
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