|Other Names||Nostrin, BM247 homolog, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, eNOS-trafficking inducer, NOSTRIN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13833c was selected from the Center region of NOSTRIN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.|
|Cellular Location||Isoform 1: Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344)|
|Tissue Location||Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over- expressed in placenta from women with pre-eclampsia (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Nitric oxide (NO) is a potent mediator in biologicprocesses such as neurotransmission, inflammatory response, andvascular homeostasis. NOSTRIN binds the enzyme responsible for NOproduction, endothelial NO synthase (ENOS; MIM 163729), andtriggers the translocation of ENOS from the plasma membrane tovesicle-like subcellular structures, thereby attenuatingENOS-dependent NO production.
Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Wiesenthal, A., et al. Traffic 10(1):26-34(2009)Schilling, K., et al. Mol. Biol. Cell 17(9):3870-3880(2006)
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