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NOSTRIN Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8IVI9
Clone Names 100405243
Peptide ID 100405243
Additional Information
Gene ID 115677
Other Names Nostrin, BM247 homolog, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, eNOS-trafficking inducer, NOSTRIN
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13833c was selected from the Center region of NOSTRIN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
Cellular Location Isoform 1: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures
Tissue Location Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over- expressed in placenta from women with pre-eclampsia (at protein level).
Research Areas
Citations (0)

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Nitric oxide (NO) is a potent mediator in biologicprocesses such as neurotransmission, inflammatory response, andvascular homeostasis. NOSTRIN binds the enzyme responsible for NOproduction, endothelial NO synthase (ENOS; MIM 163729), andtriggers the translocation of ENOS from the plasma membrane tovesicle-like subcellular structures, thereby attenuatingENOS-dependent NO production.


Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Wiesenthal, A., et al. Traffic 10(1):26-34(2009)Schilling, K., et al. Mol. Biol. Cell 17(9):3870-3880(2006)

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$ 80.00
Cat# BP13833c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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