|Other Names||Calsenilin, A-type potassium channel modulatory protein 3, DRE-antagonist modulator, DREAM, Kv channel-interacting protein 3, KChIP3, KCNIP3, CSEN, DREAM, KCHIP3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13839b was selected from the C-term region of KCNIP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CSEN, DREAM, KCHIP3|
|Function||Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane; Lipid-anchor Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus|
|Tissue Location||Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the family of voltage-gatedpotassium (Kv) channel-interacting proteins, which belong to therecoverin branch of the EF-hand superfamily. Members of this familyare small calcium binding proteins containing EF-hand-like domains.They are integral subunit components of native Kv4 channelcomplexes that may regulate A-type currents, and hence neuronalexcitability, in response to changes in intracellular calcium. Theencoded protein also functions as a calcium-regulatedtranscriptional repressor, and interacts with presenilins.Alternatively spliced transcript variants encoding differentisoforms have been described.
Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :Rivas, M., et al. Mol. Endocrinol. 23(6):862-870(2009)Jerng, H.H., et al. J. Biol. Chem. 283(51):36046-36059(2008)Fedrizzi, L., et al. J. Biol. Chem. 283(41):27494-27503(2008)Woo, H.N., et al. Neuroreport 19(12):1193-1197(2008)
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