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IL21 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9HBE4
Clone Names 100427202
Peptide ID 100427202
Additional Information
Gene ID 59067
Other Names Interleukin-21, IL-21, Za11, IL21
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13840b was selected from the C-term region of IL21. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL21
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Cellular Location Secreted.
Tissue Location Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes
Research Areas
Citations (0)

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Background

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B-and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

References

Petukhova, L., et al. Nature 466(7302):113-117(2010)Yue, F.Y., et al. J. Immunol. 185(1):498-506(2010)Pallone, F., et al. Expert Rev Clin Immunol 6(4):537-541(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Hollis-Moffatt, J.E., et al. Arthritis Res. Ther. 12 (3), R116 (2010) :

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$ 80.00
Cat# BP13840b
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