|Other Names||Carcinoembryonic antigen-related cell adhesion molecule 3, Carcinoembryonic antigen CGM1, CD66d, CEACAM3, CD66D, CGM1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13855b was selected from the C-term region of CEACAM3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the family ofcarcinoembryonic antigen-related cell adhesion molecules (CEACAMs),which are used by several bacterial pathogens to bind and invadehost cells. The encoded transmembrane protein directs phagocytosisof several bacterial species that is dependent on the small GTPaseRac. It is thought to serve an important role in controllinghuman-specific pathogens by the innate immune system. Alternativelyspliced transcript variants have been described, but theirbiological validity has not been determined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Tsavaris, N., et al. J Chemother 21(6):673-680(2009)Skubitz, K.M., et al. J Transl Med 6, 78 (2008) :Stern-Ginossar, N., et al. J. Immunol. 179(7):4424-4434(2007)Ali, C.W., et al. J Gastrointest Cancer 38 (2-4), 108-114 (2007) :
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