|Other Names||Activin receptor type-1, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13856c was selected from the Center region of ACVR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells|
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Activins are dimeric growth and differentiation factorswhich belong to the transforming growth factor-beta (TGF-beta)superfamily of structurally related signaling proteins. Activinssignal through a heteromeric complex of receptor serine kinaseswhich include at least two type I ( I and IB) and two type II (IIand IIB) receptors. These receptors are all transmembrane proteins,composed of a ligand-binding extracellular domain withcysteine-rich region, a transmembrane domain, and a cytoplasmicdomain with predicted serine/threonine specificity. Type Ireceptors are essential for signaling; and type II receptors arerequired for binding ligands and for expression of type Ireceptors. Type I and II receptors form a stable complex afterligand binding, resulting in phosphorylation of type I receptors bytype II receptors. This gene encodes activin A type I receptorwhich signals a particular transcriptional response in concert withactivin type II receptors. Mutations in this gene are associatedwith fibrodysplasia ossificans progressive.
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Song, G.A., et al. J. Biol. Chem. 285(29):22542-22553(2010)Herrera, B., et al. Cancer Res. 69(24):9254-9262(2009)Jung, B., et al. PLoS ONE 4 (12), E8308 (2009) :
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