|Other Names||Bone morphogenetic protein 2, BMP-2, Bone morphogenetic protein 2A, BMP-2A, BMP2, BMP2A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13858c was selected from the Center region of BMP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).|
|Tissue Location||Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to thetransforming growth factor-beta (TGFB) superfamily. The encodedprotein acts as a disulfide-linked homodimer and induces bone andcartilage formation.
Liu, Y., et al. Clin. Orthop. Relat. Res. 468(12):3333-3341(2010)Kupfer, S.S., et al. Gastroenterology 139(5):1677-1685(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Szczesny, G., et al. Arch Orthop Trauma Surg (2010) In press :
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