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BMP2 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P12643
Clone Names 100430063
Peptide ID 100430063
Additional Information
Gene ID 650
Other Names Bone morphogenetic protein 2, BMP-2, Bone morphogenetic protein 2A, BMP-2A, BMP2, BMP2A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13858c was selected from the Center region of BMP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMP2
Synonyms BMP2A
Function Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Cellular Location Secreted.
Tissue Location Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine
Research Areas
Citations (0)

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Background

The protein encoded by this gene belongs to thetransforming growth factor-beta (TGFB) superfamily. The encodedprotein acts as a disulfide-linked homodimer and induces bone andcartilage formation.

References

Liu, Y., et al. Clin. Orthop. Relat. Res. 468(12):3333-3341(2010)Kupfer, S.S., et al. Gastroenterology 139(5):1677-1685(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Szczesny, G., et al. Arch Orthop Trauma Surg (2010) In press :

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$ 80.00
Cat# BP13858c
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