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MDM4 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O15151
Clone Names 100430093
Peptide ID 100430093
Additional Information
Gene ID 4194
Other Names Protein Mdm4, Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, MDM4, MDMX
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13861c was selected from the Center region of MDM4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MDM4
Synonyms MDMX
Function Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Cellular Location Nucleus.
Tissue Location Expressed in all tissues tested with high levels in thymus
Research Areas
Citations (0)

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The human MDM4 gene, which plays a role in apoptosis,encodes a 490-amino acid protein containing a RING finger domainand a putative nuclear localization signal. The MDM4 putativenuclear localization signal, which all Mdm proteins contain, islocated in the C-terminal region of the protein. The mRNA isexpressed at a high level in thymus and at lower levels in allother tissues tested. MDM4 protein produced by in vitro translationinteracts with p53 via a binding domain located in the N-terminalregion of the MDM4 protein. MDM4 shows significant structuralsimilarity to p53-binding protein MDM2. Two transcript variants,one protein-coding and the other likely not to be protein-coding,have been found for this gene.


Xu, N., et al. Biochem. Biophys. Res. Commun. 401(3):417-421(2010)Sarkari, F., et al. J. Mol. Biol. 402(5):825-837(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Fang, S., et al. PLoS ONE 5 (5), E10813 (2010) :

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$ 80.00
Cat# BP13861c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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