|Other Names||Prorelaxin H1, Relaxin B chain, Relaxin A chain, RLN1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13864b was selected from the C-term region of RLN1/RLN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.|
|Tissue Location||Prostate. Not expressed in placenta, decidua or ovary.|
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Relaxins are known endocrine and autocrine/paracrinehormones, belonging to the insulin gene superfamily. In the humanthere are three non-allelic relaxin genes, RLN1, RLN2 and RLN3.RLN1 and RLN2 share high sequence homology. This encoded protein issynthesized as a single-chain polypeptide but the active formconsists of an A chain and a B chain linked by disulfide bonds;however, their exact cleavage sites have not been described.Relaxin is produced by the ovary, and targets the mammalianreproductive system to ripen the cervix, elongate the pubicsymphysis and inhibit uterine contraction. It may have additionalroles in enhancing sperm motility, regulating blood pressure,controlling heart rate and releasing oxytocin and vasopressin. Thisgene has multiple polyadenylation sites. There are multiplealternatively spliced transcript variants described for this genebut their full length nature is not known yet. [provided byRefSeq].
Radestock, Y., et al. Mol. Cancer Res. 8(4):494-506(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Ferlin, A., et al. Bone 46(2):504-513(2010)Vogel, I., et al. In Vivo 23(6):1005-1009(2009)Anumba, D.O., et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 147(1):41-45(2009)
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