|Other Names||Vesicle-associated membrane protein 7, VAMP-7, Synaptobrevin-like protein 1, Tetanus-insensitive VAMP, Ti-VAMP, VAMP7, SYBL1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13865c was selected from the Center region of VAMP7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein Cell junction, synapse, synaptosome. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).|
|Tissue Location||Detected in all tissues tested.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transmembrane protein that is a memberof the soluble N-ethylmaleimide-sensitive factor attachment proteinreceptor (SNARE) family. The encoded protein localizes to lateendosomes and lysosomes and is involved in the fusion of transportvesicles to their target membranes. Alternate splicing results inmultiple transcript variants.
Vivona, S., et al. J. Biol. Chem. 285(23):17965-17973(2010)Danglot, L., et al. J. Cell. Sci. 123 (PT 5), 723-735 (2010) :Fader, C.M., et al. Biochim. Biophys. Acta 1793(12):1901-1916(2009)Burgo, A., et al. EMBO Rep. 10(10):1117-1124(2009)Ward, D.M., et al. Mol. Biol. Cell 11(7):2327-2333(2000)
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