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CAPN11 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UMQ6
Clone Names 100430179
Additional Information
Gene ID 11131
Other Names Calpain-11, 3422-, Calcium-activated neutral proteinase 11, CANP 11, CAPN11
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13870c was selected from the Center region of CAPN11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAPN11
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Cellular Location Cytoplasmic vesicle, secretory vesicle, acrosome
Tissue Location Highest expression in testis.
Research Areas
Citations (0)
citation

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Background

Calpains constitute a family of intracellularcalcium-dependent cysteine proteases. There are eight members inthis superfamily. They consist of a variable 80 kDa subunit and aninvariant 30 kDa subunit. This calpain protein appears to haveprotease activity and calcium-binding ability. A similar mouseprotein may play a functional role in spermatogenesis and in theregulation of calcium-dependent signal transduction events duringmeiosis.

References

Ben-Aharon, I., et al. Mol. Reprod. Dev. 73(6):767-773(2006)Dear, T.N., et al. Genomics 59(2):243-247(1999)Rojas, F.J., et al. Mol. Hum. Reprod. 5(6):520-526(1999)Saido, T.C., et al. FASEB J. 8(11):814-822(1994)Melloni, E., et al. Trends Neurosci. 12(11):438-444(1989)

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$ 277.78
Cat# BP13870c
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Availability: 2 weeks
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