|Other Names||Calpain-11, 3422-, Calcium-activated neutral proteinase 11, CANP 11, CAPN11|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13870c was selected from the Center region of CAPN11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, acrosome|
|Tissue Location||Highest expression in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Calpains constitute a family of intracellularcalcium-dependent cysteine proteases. There are eight members inthis superfamily. They consist of a variable 80 kDa subunit and aninvariant 30 kDa subunit. This calpain protein appears to haveprotease activity and calcium-binding ability. A similar mouseprotein may play a functional role in spermatogenesis and in theregulation of calcium-dependent signal transduction events duringmeiosis.
Ben-Aharon, I., et al. Mol. Reprod. Dev. 73(6):767-773(2006)Dear, T.N., et al. Genomics 59(2):243-247(1999)Rojas, F.J., et al. Mol. Hum. Reprod. 5(6):520-526(1999)Saido, T.C., et al. FASEB J. 8(11):814-822(1994)Melloni, E., et al. Trends Neurosci. 12(11):438-444(1989)
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