|Other Names||Potassium voltage-gated channel subfamily C member 2, Voltage-gated potassium channel Kv32, KCNC2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13871b was selected from the C-term region of KCNC2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The Shaker gene family of Drosophila encodes components ofvoltage-gated potassium channels and is comprised of foursubfamilies. Based on sequence similarity, this gene is similar toone of these subfamilies, namely the Shaw subfamily. The proteinencoded by this gene belongs to the delayed rectifier class ofchannel proteins and is an integral membrane protein that mediatesthe voltage-dependent potassium ion permeability of excitablemembranes. Three transcript variants encoding three differentisoforms have been found for this gene.
Wang, Z., et al. J. Gen. Physiol. 133(4):361-374(2009)Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)Haas, M., et al. Mamm. Genome 4(12):711-715(1993)
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