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PTF1A Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q7RTS3
Clone Names 100430214
Peptide ID 100430214
Additional Information
Gene ID 256297
Other Names Pancreas transcription factor 1 subunit alpha, Class A basic helix-loop-helix protein 29, bHLHa29, Pancreas-specific transcription factor 1a, bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, PTF1-p48, PTF1A, BHLHA29, PTF1P48
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13876b was selected from the C-term region of PTF1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTF1A
Synonyms BHLHA29, PTF1P48
Function Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. Cytoplasm. Note=In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity).
Tissue Location Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers
Research Areas
Citations (0)

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This gene encodes a protein that is a component of thepancreas transcription factor 1 complex (PTF1) and is known to havea role in mammalian pancreatic development. The protein plays arole in determining whether cells allocated to the pancreatic budscontinue towards pancreatic organogenesis or revert back toduodenal fates. The protein is thought to be involved in themaintenance of exocrine pancreas-specific gene expression includingelastase 1 and amylase. Mutations in this gene cause cerebellaragenesis and loss of expression is seen in ductal type pancreascancers.


Meredith, D.M., et al. J. Neurosci. 29(36):11139-11148(2009)Rodolosse, A., et al. Biochem. J. 418(2):463-473(2009)Tutak, E., et al. Genet. Couns. 20(2):147-152(2009)Yamada, M., et al. J. Neurosci. 27(41):10924-10934(2007)Beres, T.M., et al. Mol. Cell. Biol. 26(1):117-130(2006)

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$ 80.00
Cat# BP13876b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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