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LRDD Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9HB75
Clone Names 100324030
Peptide ID 100324030
Additional Information
Gene ID 55367
Other Names p53-induced death domain-containing protein 1, Leucine-rich repeat and death domain-containing protein, PIDD1, LRDD, PIDD
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13884b was selected from the C-term region of LRDD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIDD1
Synonyms LRDD, PIDD
Function Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.
Cellular Location Cytoplasm. Nucleus
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Background

LRDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.

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$ 80.00
Cat# BP13884b
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