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DNASE1L3 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q13609
Clone Names 100324107
Peptide ID 100324107
Additional Information
Gene ID 1776
Other Names Deoxyribonuclease gamma, DNase gamma, 3121-, DNase I homolog protein DHP2, Deoxyribonuclease I-like 3, DNase I-like 3, Liver and spleen DNase, LS-DNase, LSD, DNASE1L3, DHP2, DNAS1L3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13885a was selected from the N-term region of DNASE1L3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNASE1L3
Synonyms DHP2, DNAS1L3
Function Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'- OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PubMed:9070308, PubMed:9714828, PubMed:14646506, PubMed:10807908, PubMed:27293190). Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis (PubMed:23229555, PubMed:24312463). The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:27293190).
Cellular Location Nucleus. Endoplasmic reticulum. Secreted. Note=Translocates from the endoplasmic reticulum to the nucleus during apoptosis (PubMed:23229555). Contradictory reports exist about the subcellular localization under normal physiological conditions Under conditions of cell death, may diffuse and/or be actively transported to the nucleus. {ECO:0000269|PubMed:23229555, ECO:0000305}
Tissue Location Liver and spleen.
Research Areas
Citations (0)

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Background

This gene encodes a member of the DNase family. Theprotein hydrolyzes DNA, is not inhibited by actin, and mediates thebreakdown of DNA during apoptosis. Alternate transcriptional splicevariants of this gene have been observed but have not beenthoroughly characterized.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ueki, M., et al. Clin. Chim. Acta 407 (1-2), 20-24 (2009) :Mizuta, R., et al. Biomed. Res. 30(3):165-170(2009)Boulares, H., et al. Biochem. Biophys. Res. Commun. 341(2):653-662(2006)Okamoto, M., et al. Biochem. Biophys. Res. Commun. 327(1):76-83(2005)

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$ 80.00
Cat# BP13885a
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