|Other Names||Deoxyribonuclease gamma, DNase gamma, 3121-, DNase I homolog protein DHP2, Deoxyribonuclease I-like 3, DNase I-like 3, Liver and spleen DNase, LS-DNase, LSD, DNASE1L3, DHP2, DNAS1L3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13885a was selected from the N-term region of DNASE1L3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.|
|Cellular Location||Nucleus. Note=May first pass through the ER membrane before being imported in the nucleus|
|Tissue Location||Liver and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the DNase family. Theprotein hydrolyzes DNA, is not inhibited by actin, and mediates thebreakdown of DNA during apoptosis. Alternate transcriptional splicevariants of this gene have been observed but have not beenthoroughly characterized.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ueki, M., et al. Clin. Chim. Acta 407 (1-2), 20-24 (2009) :Mizuta, R., et al. Biomed. Res. 30(3):165-170(2009)Boulares, H., et al. Biochem. Biophys. Res. Commun. 341(2):653-662(2006)Okamoto, M., et al. Biochem. Biophys. Res. Commun. 327(1):76-83(2005)
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