|Other Names||Dual specificity protein phosphatase 9, Mitogen-activated protein kinase phosphatase 4, MAP kinase phosphatase 4, MKP-4, DUSP9, MKP4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13891b was selected from the C-term region of DUSP9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inactivates MAP kinases. Has a specificity for the ERK family.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the dualspecificity protein phosphatase subfamily. These phosphatasesinactivate their target kinases by dephosphorylating both thephosphoserine/threonine and phosphotyrosine residues. Theynegatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associatedwith cellular proliferation and differentiation. Different membersof the family of dual specificity phosphatases show distinctsubstrate specificities for various MAP kinases, different tissuedistribution and subcellular localization, and different modes ofinducibility of their expression by extracellular stimuli. Thisgene product shows selectivity for members of the ERK family of MAPkinases, is expressed only in placenta, kidney, and fetal liver,and is localized to the cytoplasm and nucleus. [provided byRefSeq].
Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)Liu, Y., et al. Cancer Res. 67(22):10711-10719(2007)Ross, M.T., et al. Nature 434(7031):325-337(2005)Muda, M., et al. J. Biol. Chem. 272(8):5141-5151(1997)
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