|Other Names||Matrix metalloproteinase-20, MMP-20, 3424-, Enamel metalloproteinase, Enamelysin, MMP20|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13895b was selected from the C-term region of MMP20. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed specifically in the enamel organ.|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. The protein encoded by this genedegrades amelogenin, the major protein component of dental enamelmatrix, and so the protein is thought to play a role in toothenamel formation. A mutation in this gene, which alters the normalsplice pattern and results in premature termination of the encodedprotein, has been associated with amelogenesis imperfecta. Thisgene is part of a cluster of MMP genes that localizes to chromosome11q22.3.
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Wojciechowski, R., et al. Invest. Ophthalmol. Vis. Sci. (2010) In press :Lee, S.K., et al. J. Dent. Res. 89(1):46-50(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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