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CHRNA7 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P36544
Clone Names 100430243
Peptide ID 100430243
Additional Information
Gene ID 1139;89832
Other Names Neuronal acetylcholine receptor subunit alpha-7, CHRNA7, NACHRA7
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13898a was selected from the N-term region of CHRNA7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NACHRA7
Function After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Cellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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The nicotinic acetylcholine receptors (nAChRs) are membersof a superfamily of ligand-gated ion channels that mediate fastsignal transmission at synapses. The nAChRs are thought to behetero-pentamers composed of homologous subunits. The proposedstructure for each subunit is a conserved N-terminal extracellulardomain followed by three conserved transmembrane domains, avariable cytoplasmic loop, a fourth conserved transmembrane domain,and a short C-terminal extracellular region. The protein encoded bythis gene forms a homo-oligomeric channel, displays markedpermeability to calcium ions and is a major component of brainnicotinic receptors that are blocked by, and highly sensitive to,alpha-bungarotoxin. Once this receptor binds acetylcholine, itundergoes an extensive change in conformation that affects allsubunits and leads to opening of an ion-conducting channel acrossthe plasma membrane. This gene is located in a region identified asa major susceptibility locus for juvenile myoclonic epilepsy and achromosomal location involved in the genetic transmission ofschizophrenia. An evolutionarily recent partial duplication eventin this region results in a hybrid containing sequence from thisgene and a novel FAM7A gene. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.


Chernyavsky, A.I., et al. Am. J. Physiol., Cell Physiol. 299 (5), C903-C911 (2010) :Saccone, N.L., et al. Genes Brain Behav. 9(7):741-750(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Jin, Y., et al. Int. J. Immunogenet. (2010) In press :Schraufstatter, I.U., et al. J Stem Cells 4(4):203-215(2009)

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$ 80.00
Cat# BP13898a
Availability: In Stock
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