|Other Names||Occludin, OCLN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13901b was selected from the C-term region of OCLN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Cell junction, tight junction|
|Tissue Location||Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis|
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This gene encodes an integral membrane protein which islocated at tight junctions. This protein may be involved in theformation and maintenance of the tight junction. The possibilityof several alternatively spliced products has been suggested butthe full nature of these products has not been described. [providedby RefSeq].
Liu, S., et al. Virology 407(1):160-170(2010)Michta, M.L., et al. J. Virol. 84(22):11696-11708(2010)O'Driscoll, M.C., et al. Am. J. Hum. Genet. 87(3):354-364(2010)Van Itallie, C.M., et al. J. Cell. Sci. 123 (PT 16), 2844-2852 (2010) :Raikwar, N.S., et al. Am. J. Physiol. Renal Physiol. 299 (2), F436-F444 (2010) :
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