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Mouse Cdk16 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q04735 |
|---|---|
| Clone Names | 110316086 |
| Gene ID | 18555 |
|---|---|
| Other Names | Cyclin-dependent kinase 16, CRK5, Cell division protein kinase 16, PCTAIRE-motif protein kinase 1, Serine/threonine-protein kinase PCTAIRE-1, Cdk16, Crk5, Pctaire1, Pctk1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13909a was selected from the N-term region of Mouse Cdk16. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Cdk16 |
|---|---|
| Synonyms | Crk5, Pctaire1, Pctk1 |
| Function | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Can phosphorylate CCNY at 'Ser-336' (in vitro) (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q63686} Cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q00536}; Cytoplasmic side {ECO:0000250|UniProtKB:Q00536}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q63686}. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY {ECO:0000250|UniProtKB:Q00536} |
| Tissue Location | Highly expressed in testis and brain, and detected at lower levels in heart, skeletal muscle, adipose tissue, lung, spleen and pancreas (at protein level). Ubiquitous with highest levels in testis and brain, with longer form predominant in all tissues except the testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cdk16 may play a role in signal transduction cascades in terminally differentiated cells.
References
Mokalled, M.H., et al. Development 137(14):2365-2374(2010)Savarese, F., et al. Mol. Cell. Biol. 26(19):7167-7177(2006)Nolen, L.D., et al. Dev. Biol. 279(2):525-540(2005)Cheng, K., et al. J. Biol. Chem. 277(35):31988-31993(2002)Besset, V., et al. Cell Growth Differ. 10(3):173-181(1999)
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