|Other Names||Cyclin-dependent kinase 16, CRK5, Cell division protein kinase 16, PCTAIRE-motif protein kinase 1, Serine/threonine-protein kinase PCTAIRE-1, Cdk16, Crk5, Pctaire1, Pctk1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13909a was selected from the N-term region of Mouse Cdk16. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||Crk5, Pctaire1, Pctk1|
|Function||Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Can phosphorylate CCNY at 'Ser-336' (in vitro) (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development.|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell junction, synapse, synaptosome Note=Colocalizes with insulin in pancreas islets.|
|Tissue Location||Highly expressed in testis and brain, and detected at lower levels in heart, skeletal muscle, adipose tissue, lung, spleen and pancreas (at protein level). Ubiquitous with highest levels in testis and brain, with longer form predominant in all tissues except the testis|
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Provided below are standard protocols that you may find useful for product applications.
Cdk16 may play a role in signal transduction cascades in terminally differentiated cells.
Mokalled, M.H., et al. Development 137(14):2365-2374(2010)Savarese, F., et al. Mol. Cell. Biol. 26(19):7167-7177(2006)Nolen, L.D., et al. Dev. Biol. 279(2):525-540(2005)Cheng, K., et al. J. Biol. Chem. 277(35):31988-31993(2002)Besset, V., et al. Cell Growth Differ. 10(3):173-181(1999)
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