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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Mouse Mknk2 Antibody (N-term) Blocking peptide   

Mouse Mknk2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8CDB0
Clone Names 110316272
Peptide ID 110316272
Additional Information
Gene ID 17347
Other Names MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2, Mknk2, Mnk2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13922a was selected from the N-term region of Mouse Mknk2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mknk2
Synonyms Mnk2
Function Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
Cellular Location Cytoplasm. Nucleus, PML body
Tissue Location Ubiquitously expressed in all tissues examined, with high levels in skeletal muscle and low levels in brain.
Research Areas
Citations (0)

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Mknk2 may play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).


Ueda, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):13984-13990(2010)Furic, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14134-14139(2010)Joshi, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):12097-12102(2009)Chrestensen, C.A., et al. Genes Cells 12(10):1133-1140(2007)Shenberger, J.S., et al. Int. J. Biochem. Cell Biol. 39(10):1828-1842(2007)

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$ 80.00
Cat# BP13922a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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