|Other Names||MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2, Mknk2, Mnk2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13922a was selected from the N-term region of Mouse Mknk2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.|
|Cellular Location||Cytoplasm. Nucleus, PML body|
|Tissue Location||Ubiquitously expressed in all tissues examined, with high levels in skeletal muscle and low levels in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Mknk2 may play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).
Ueda, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):13984-13990(2010)Furic, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14134-14139(2010)Joshi, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):12097-12102(2009)Chrestensen, C.A., et al. Genes Cells 12(10):1133-1140(2007)Shenberger, J.S., et al. Int. J. Biochem. Cell Biol. 39(10):1828-1842(2007)
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